| Date: | 4–10 April 2022 |
| Edition: | 2nd |
| Surface: | Clay / Outdoor |
| Location: | Oeiras, Portugal |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $80,000 |
| Champs: |  Elisabetta Cocciaretto |
| Champd: |  Katarzyna Piter /  Kimberley Zimmermann |
The 2022 Oeiras Ladies Open was a professional tennis tournament played on outdoor clay courts. It was the second edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Oeiras, Portugal between 4 and 10 April 2022.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Varvara Gracheva | 71 | 1 | ||
 France | ||||
| France | ||||
| France | Diane Parry | 98 | 4 | |
| France | Kristina Mladenovic | 100 | 5 | |
| Vitalia Diatchenko | 105 | 6 | ||
| France | Chloé Paquet | 106 | 7 | |
 Hungary | Dalma Gálfi | 107 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry using a junior exempt:
The following player received entry as a special exempt:
The following players received entry from the qualifying draw:
Elisabetta Cocciaretto
Ingrid Gamarra Martins
Justina Mikulskytė
Andreea Mitu
Ashley Lahey Stefania RubiniThe following players received entry as lucky losers:
See main article: 2022 Oeiras Ladies Open – Singles.
Elisabetta Cocciaretto def. Viktoriya Tomova, 7–6(7–5), 2–6, 7–5See main article: 2022 Oeiras Ladies Open – Doubles.
Katarzyna Piter / Kimberley Zimmermann def. Katharina Gerlach / 
Natalija Stevanović 6–1, 6–1
