| Date: | 14–21 August 2022 |
| Edition: | 15th (men) 18th (women) |
| Surface: | Hard |
| Location: | Vancouver, Canada |
| Venue: | Hollyburn Country Club |
| Category: | ATP Challenger 125 WTA 125 |
| Prize Money: | $159,360 (men) $115,000 (women) |
| Draw: | 32S/16D |
| Champms: |  Constant Lestienne |
| Champmd: |  André Göransson /  Ben McLachlan |
| Champws: | Valentini Grammatikopoulou |
| Champwd: | Miyu Kato /  Asia Muhammad |
| Before Year: | 2019 |
| Main Name: | Vancouver Open |
The 2022 Odlum Brown Vancouver Open was a professional tennis tournament played on outdoor hard courts. It was the fifteenth edition of the men's event and eighteenth of the women's, which are also part of the 2022 ATP Challenger Tour[1] and the 2022 WTA 125 tournaments[2] respectively. It was also the first edition of the women's event as a WTA 125 after being upgraded from the ITF 100K tournament. It took place in Vancouver, Canada between 14 and 21 August 2022. The tournament could not be staged in 2020 and 2021 due to the COVID-19 pandemic.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Japan | Yoshihito Nishioka | 54 | 1 | |
 Czech Republic | Jiří Veselý | 66 | 2 | |
| France | Arthur Rinderknech | 67 | 3 | |
| Sweden | Mikael Ymer | 77 | 4 | |
| France | Constant Lestienne | 90 | 5 | |
 Lithuania | Ričardas Berankis | 98 | 6 | |
| Nicolás Jarry | 105 | 7 | ||
| Marc-Andrea Hüsler | 111 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Alafia Ayeni Ulises Blanch Clément Chidekh Laurent Lokoli Govind Nanda
Luke Saville| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| United States | Madison Brengle | 64 | 1 | |
 Italy | Lucia Bronzetti | 65 | 2 | |
| United States | Claire Liu | 81 | 3 | |
 China | Wang Xinyu | 83 | 4 | |
| Sweden | Rebecca Peterson | 88 | 5 | |
 Canada | Rebecca Marino | 96 | 6 | |
 Belgium | Greet Minnen | 97 | 7 | |
| Japan | Misaki Doi | 98 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
Katie Boulter → replaced by 
Maja Chwalińska
Victoria Jiménez Kasintseva Jaimee Fourlis → replaced by Emma Navarro Linda Fruhvirtová → replaced by Astra Sharma Greet Minnen → replaced by Arianne Hartono Wang Qiang → replaced by Kurumi Nara Catherine Harrison (right foot injury)| Country | Player | Country | Player | Rank† | Seed | |
|---|---|---|---|---|---|---|
| Japan | Miyu Kato | United States | Asia Muhammad | 103 | 1 | |
| Japan | Misaki Doi | Sweden | Rebecca Peterson | 212 | 2 | |
| Japan | Nao Hibino |  Georgia | Oksana Kalashnikova | 217 | 3 | |
 Hungary | Tímea Babos | United States | Angela Kulikov | 230 | 4 |
The following pair received a wildcard entry into main draw:
Tímea Babos / Greet Minnen → replaced by Rebecca Marino / Heather Watson Emina Bektas / Catherine Harrison → replaced by 
Ingrid Gamarra Martins / Emily Webley-Smith Sophie Chang / Angela Kulikov → replaced by Astra Sharma / CoCo Vandeweghe Astra Sharma / CoCo Vandeweghe (Vandeweghe – right shoulder injury)See main article: 2022 Odlum Brown Vancouver Open – Men's singles.
Constant Lestienne def. Arthur Rinderknech 6–0, 4–6, 6–3.See main article: 2022 Odlum Brown Vancouver Open – Women's singles.
Lucia Bronzetti, 6–2, 6–4See main article: 2022 Odlum Brown Vancouver Open – Men's doubles.
André Göransson / Ben McLachlan def. Treat Huey / John-Patrick Smith 6–7(4–7), 7–6(9–7), [11–9].See main article: 2022 Odlum Brown Vancouver Open – Women's doubles.
Miyu Kato / Asia Muhammad def. Tímea Babos / Angela Kulikov, 6–3, 7–5