| Date: | 29 August – 4 September |
| Edition: | 2nd |
| Surface: | Hard |
| Location: | Nonthaburi, Thailand |
| Champs: |  Arthur Cazaux |
| Champd: | Benjamin Lock /  Yuta Shimizu |
| Before Name: | Nonthaburi Challenger |
| Before Year: | 2022 |
| Main Name: | Nonthaburi Challenger |
| After Name: | Nonthaburi Challenger III |
| After Year: | 2022 |
The 2022 Nonthaburi Challenger II was a professional tennis tournament played on hard courts. It was the 2nd edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Nonthaburi, Thailand from 29 August to 4 September 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Japan | Yosuke Watanuki | 229 | 1 | |
 United Kingdom | Alastair Gray | 256 | 2 | |
| Japan | ||||
 Kazakhstan | Denis Yevseyev | 266 | 4 | |
 Brazil | Gabriel Décamps | 280 | 5 | |
| United Kingdom | Billy Harris | 298 | 6 | |
 Ukraine | Illya Marchenko | 308 | 7 | |
The following players received wildcards into the singles main draw:
Thanapet Chanta Krittin Koaykul Kasidit SamrejThe following player received entry into the singles main draw as a special exempt:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
See main article: 2022 Nonthaburi Challenger II – Singles.
Arthur Cazaux def. 
Omar Jasika 7–6(8–6), 6–4.See main article: 2022 Nonthaburi Challenger II – Doubles.
Yuta Shimizu def. Francis Alcantara / Christopher Rungkat 6–1, 6–3.
