| Champ: |  Coco Gauff Jessica Pegula |
| Runner: | Nicole Melichar-Martinez Ellen Perez |
| Score: | 6–4, 6–7(5–7), [10–5] |
See main article: 2022 National Bank Open.
Coco Gauff and Jessica Pegula defeated Nicole Melichar-Martinez and Ellen Perez in the final, 6–4, 6–7(5–7), [10–5] to win the women's doubles tennis title at the 2022 Canadian Open. With the win, Gauff gained the WTA No. 1 doubles ranking for the first time and became the second-youngest player in history to attain the No. 1 ranking, after Martina Hingis in 1997.[1] Elise Mertens and Zhang Shuai were also in contention for the top ranking.
Gabriela Dabrowski and Luisa Stefani were the reigning champions,[2] but Stefani did not return due to injury. Dabrowski partnered with Giuliana Olmos, but lost in the semifinals to Melichar-Martinez and Perez.[3]
The top four seeds received a bye into the second round.
The following are the seeded teams, based on WTA rankings as of August 1, 2022.
Marie Bouzková / Laura Siegemund (Bouzková – back injury) Lucie Hradecká / 
Sania Mirza → replaced by Madison Keys / Sania Mirza
Monica Niculescu / Elena-Gabriela Ruse → replaced by Vivian Heisen / Monica Niculescu
Belgium
Canada
Mexico
China
Ukraine
Brazil