| Champ: | Wesley Koolhof Neal Skupski |
| Runner: | Dan Evans John Peers |
| Score: | 6–2, 4–6, [10–6] |
See main article: 2022 National Bank Open.
Wesley Koolhof and Neal Skupski defeated Dan Evans and John Peers in the final, 6–2, 4–6, [10–6] to win the men's doubles tennis title at the 2022 Canadian Open. It marked their second ATP Masters 1000 title together and sixth title of the season.[1]
Rajeev Ram and Joe Salisbury were the defending champions,[2] but lost in the second round to Ariel Behar and Gonzalo Escobar.
The top four seeds received a bye into the second round.
The following are the seeded teams, based on ATP rankings as of August 1, 2022.
| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
 United States | Rajeev Ram | United Kingdom | Joe Salisbury | 3 | 1 | |
 Spain | Marcel Granollers |  Argentina | Horacio Zeballos | 7 | 2 | |
| Wesley Koolhof | United Kingdom | Neal Skupski | 11 | 3 | ||
| Marcelo Arévalo | Jean-Julien Rojer | 17 | 4 | |||
| Nikola Mektić | Mate Pavić | 19 | 5 | |||
| Tim Pütz |  New Zealand | Michael Venus | 21 | 6 | ||
| Ivan Dodig | United States | Austin Krajicek | 35 | 7 | ||
 Colombia | Juan Sebastián Cabal | Colombia | Robert Farah | 40 | 8 |
Hubert Hurkacz / John Isner → replaced by Hubert Hurkacz / Jan Zieliński
Marko Stakusic / Jaden Weekes → replaced by Francisco Cerúndolo / Diego Schwartzman