| Champ: |  Pablo Carreño Busta |
| Runner: |  Hubert Hurkacz |
| Score: | 3–6, 6–3, 6–3 |
| Draw: | 56 |
| Seeds: | 16 |
| Main Name: | Canadian Open (tennis) Canadian Open |
See main article: 2022 National Bank Open.
Pablo Carreño Busta defeated Hubert Hurkacz in the final, 3–6, 6–3, 6–3 to win the men's singles tennis title at the 2022 Canadian Open. Carreño Busta's first title of the season was also his maiden ATP Masters 1000 title. Hurkacz's defeat in the contest for his second Masters 1000 title was also a career-first loss in a tour-level final after he was bidding to win a sixth title in six finals.[1]
Daniil Medvedev was the defending champion,[2] but lost in the second round to Nick Kyrgios.[3]
For the first time since 1999 Indian Wells, the top three seeds at a Masters 1000 tournament were defeated in their opening matches.[4] Jannik Sinners loss in the third round also guaranteed a maiden Masters 1000 finalist in the bottom half of the draw, from which Carreño Busta emerged.
The top eight seeds receive a bye into the second round.
The following are the seeded players. Seedings are based on ATP rankings as of August 1, 2022. Rank and points before are as of August 8, 2022.
Points for the 2021 tournament were not mandatory and are included in the table below only if they counted towards the player's ranking as of August 8, 2022. Players who are not defending points from the 2021 tournament will instead have their 19th best result replaced by their points from the 2022 tournament. Points from the 2019 tournament are being dropped on August 8, 2022, and are accordingly not reflected in this table.
| Seed | Rank | Player | Points before | Points defending (or 19th best result)† | Points won | Points after | Status | |
|---|---|---|---|---|---|---|---|---|
| 1 | 1 | Daniil Medvedev | 7,875 | 1,000 | 10 | 6,885 | ||
| 2 | 4 | Carlos Alcaraz | 5,035 | (0) | 10 | 5,045 | ||
| 3 | 5 | Stefanos Tsitsipas | 5,000 | 360 | 10 | 4,650 | Second round lost to  Jack Draper [Q] | |
| 4 | 7 |  Casper Ruud | 4,685 | 180 | 360 | 4,865 | Semifinals lost to Hubert Hurkacz [8] | |
| 5 | 8 | Andrey Rublev | 3,710 | 90 | 10 | 3,630 | Second round lost to Dan Evans | |
| 6 | 9 |  Félix Auger-Aliassime | 3,490 | (45) | 180 | 3,625 | Quarterfinals lost to Casper Ruud [4] | |
| 7 | 12 |  Jannik Sinner | 2,895 | 10 | 90 | 2,975 | Third round lost to Pablo Carreño Busta | |
| 8 | 10 | Hubert Hurkacz | 3,015 | 180 | 600 | 3,435 | Runner-up, lost to Pablo Carreño Busta | |
| 9 | 11 | Cameron Norrie | 2,985 | 10 | 90 | 3,065 | Third round lost to Félix Auger-Aliassime [6] | |
| 10 | 13 |  Taylor Fritz | 2,860 | (20) | 90 | 2,930 | Third round lost to Dan Evans | |
| 11 | 14 | Matteo Berrettini | 2,430 | (0) | 10 | 2,440 | First round lost to Pablo Carreño Busta | |
| 12 | 15 |  Diego Schwartzman | 2,245 | 90 | 45 | 2,200 | Second round lost to Albert Ramos Viñolas | |
| 13 | 16 | Marin Čilić | 2,085 | 45 | 90 | 2,130 | Third round lost to Tommy Paul | |
| Reilly Opelka | 2,010 | 600 | 0 | 1,410 | Withdrew due to heel injury | |||
| 15 | 18 | Roberto Bautista Agut | 1,850 | 180 | 90 | 1,760 | Third round lost to Casper Ruud [4] | |
| 16 | 19 | Grigor Dimitrov | 1,775 | 10 | 45 | 1,810 | Second round lost to  Alex de Minaur | |
| 17 | 20 |  Gaël Monfils | 1,615 | 180 | 90 | 1,525 | Third round retired against Jack Draper [Q] |
The following players would have been seeded, but withdrew before the tournament began.
| Rank | Player | Points before | Points defending (or 19th best result) | Points after | Withdrawal reason | |
|---|---|---|---|---|---|---|
| 2 | Alexander Zverev | 6,760 | (0) | 6,760 | Right ankle injury | |
| 3 | Rafael Nadal[5] | 5,620 | (0) | 5,620 | Abdominal injury | |
| 6 |  Novak Djokovic[6] | 4,770 | (0) | 4,770 | Failure to meet COVID-19 vaccination requirement for entry into Canada |
