| Competition: | NISA Nation |
| Prevseason: | 2021 |
| Nextseason: | 2022–23 |
The 2022 NISA Nation season was the second season of NISA Nation, the National Independent Soccer Association's amateur league.
| Team | City | Stadium | Founded | First season | |
|---|---|---|---|---|---|
| Athletico Orlando | Orlando, Florida | Northeast Regional Park | 2017 | 2022 | |
| Club De Lyon FC | Orlando, Florida | Northeast Regional Park | 2021 | 2022 | |
| Deportivo Lake Mary | Lake Mary, Florida | Lake Mary High School | 2017 | 2022 | |
| Inter United FC | Davenport, Florida | Feltrim Sports Complex | 1997 | 2022 | |
| Winter Haven United FC | Winter Haven, Florida | Feltrim Sports Complex | 2016 | 2022 |
| Team | City | Stadium | Founded | First season | |
|---|---|---|---|---|---|
| Aiolikos FC USA Rush | Boston, Massachusetts | Cawley Memorial Stadium | 1975 | 2022 | |
| Albion SC Delaware | Middletown, Delaware | DE Turf Sports Complex | 2020 | 2021 | |
| Allentown United FC | Allentown, Pennsylvania | Cedar Crest College | 2018 | 2022 | |
| Atlantic City FC | Atlantic City, New Jersey | Rowan University | 2017 | 2021 | |
| Boston Athletic SC | Boston, Massachusetts | Harry Della Russo Stadium | 2005 | 2022 | |
| New Jersey Alliance FC | Clifton, New Jersey | Newark Schools Stadium | 2012 | 2021 | |
| New York Braveheart SC | New York, New York | Orlin and Cohen Sports Complex | 2022 | 2022 | |
| Union SC | Union Township, New Jersey | Volunteer Field | 1984 | 2022 |
| Team | City | Stadium | Founded | First season | |
|---|---|---|---|---|---|
| AFC Solano | Fairfield, California | Armijo High School | 2020 | 2022 | |
| AFC South Bay | San Jose, California | Watson Park Soccer Fields | 2021 | 2022 | |
| Battleborn FC | Minden, Nevada | Douglas High School | 2021 | 2022 | |
| San Francisco Elite Metro FC | San Francisco, California | Negoesco Stadium | 2017 | 2022 |
| Team | City | Stadium | Founded | First season | |
|---|---|---|---|---|---|
| Capo FC | San Juan Capistrano, California | JSerra Catholic High School | 2006 | 2022 | |
| FC Golden State Force | Pomona, California | No fixed stadium | 2015 | 2021 | |
| Las Vegas Legends | Las Vegas, Nevada | Peter Johann Memorial Field | 2012 | 2021 | |
| Oaks FC | Thousand Oaks, California | California Lutheran University | 1979 | 2022 | |
| Sporting ID11 | Lake Forest, California | Lake Forest Sports Complex | 2021 | 2022 | |
| Valley FC Raiders | Gilbert, Arizona | Mesquite High School | 2021 | 2022 |
The 2022 season saw the addition of Florida and Pacific Regions. In each region, the team with the most points at the end of the season is the champion. There are no playoffs or national championship.