| Champ: |  Gabriela Dabrowski  Giuliana Olmos |
| Runner: |  Desirae Krawczyk Demi Schuurs |
| Score: | 7–6(7–1), 5–7, [10–7] |
| Before Name: | Mutua Madrid Open – Women's doubles |
| After Name: | Mutua Madrid Open – Women's doubles |
See main article: article and 2022 Mutua Madrid Open.
Gabriela Dabrowski and Giuliana Olmos defeated Desirae Krawczyk and Demi Schuurs in the final, 7–6(7–1), 5–7, [10–7] to win the women's doubles tennis title at the 2022 Madrid Open. This was Dabrowski's third consecutive final at the tournament, having lost the previous two editions in 2021 and 2019.
Barbora Krejčíková and Kateřina Siniaková were the defending champions,[1] but Krejčíková could not defend her title due to injury. Siniaková played alongside Leylah Fernandez, but lost in the second round to Ulrikke Eikeri and Tereza Mihalíková.
The two top seeds received a bye into the second round.
The following are the seeded teams, based on WTA rankings as of April 25, 2022.
Ulrikke Eikeri / Catherine Harrison → replaced by Ulrikke Eikeri / 
Tereza Mihalíková
Lucie Hradecká / 
Sania Mirza → replaced by Kaitlyn Christian / 
Oksana Kalashnikova
Nadiia Kichenok / 
Raluca Olaru → replaced by Nadiia Kichenok / Ekaterine Gorgodze
Elise Mertens → replaced by 
Elena Rybakina / Liudmila Samsonova Tereza Martincová / Markéta Vondroušová → replaced by Julia Lohoff / Renata Voráčová Monica Niculescu → replaced by Alexandra Panova / 
Han Xinyun
Australia
Brazil
Japan