| Score: | 6–7(4–7), 6–4, [10–5] |
See main article: article and 2022 Mutua Madrid Open.
Wesley Koolhof and Neal Skupski defeated Juan Sebastián Cabal and Robert Farah in the final, 6–7(4–7), 6–4, [10–5] to win the men's doubles tennis title at the 2022 Madrid Open. It was their first ATP Masters 1000 title.
Marcel Granollers and Horacio Zeballos were the defending champions,[1] but lost in the quarterfinals to Cabal and Farah.
This tournament marked the final professional appearance of former doubles world No. 3 and Olympic gold medalist Marc López.[2]
The following are the seeded teams, based on ATP rankings as of April 25, 2022.
Taylor Fritz / Reilly Opelka → replaced by 
Federico Delbonis / Andrés Molteni
Sander Gillé / Joran Vliegen → replaced by 
Nikoloz Basilashvili / 
Alexander Bublik
Michael Venus → replaced by 
Jamie Murray / Michael Venus
Spain
France
Colombia
Australia
Slovakia