The 2022 Moselle Open was a men's tennis tournament played on indoor hard courts. It was the 19th edition of the event, and it is part of the ATP Tour 250 Series of the 2022 ATP Tour. It took place at the Arènes de Metz from 19 September to 25 September 2022.[1]
See main article: 2022 Moselle Open – Singles.
Lorenzo Sonego def. 
Alexander Bublik, 7–6(7–3), 6–2See main article: 2022 Moselle Open – Doubles.
Jan Zieliński def. 
Lloyd Glasspool / 
Harri Heliövaara, 7–6(7–5), 6–4| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Daniil Medvedev[2] | 4 | 1 | ||
| Poland | Hubert Hurkacz | 10 | 2 | |
| Italy | Lorenzo Musetti | 30 | 3 | |
| Holger Rune | 31 | 4 | ||
 Georgia | Nikoloz Basilashvili | 36 | 5 | |
| Aslan Karatsev | 39 | 6 | ||
| Kazakhstan | Alexander Bublik | 44 | 7 | |
 France | Adrian Mannarino | 47 | 8 |
The following players received wildcards into the singles main draw:
The following player was accepted directly into the main draw using a protected ranking:
The following players received entry from the qualifying draw:
Pablo Carreño Busta → replaced by Lorenzo Sonego
Maxime Cressy → replaced by João Sousa Alejandro Davidovich Fokina → replaced by 
Jiří Lehečka Arthur Rinderknech
Mikael Ymer Adrian Mannarino
Filip Krajinović → replaced by 
David Goffin Gaël Monfils → replaced by Hugo Gaston| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Tim Pütz |  New Zealand | Michael Venus | 15 | 1 | ||
| United Kingdom | Lloyd Glasspool | Finland | Harri Heliövaara | 39 | 2 | |
| France | Nicolas Mahut | France | Édouard Roger-Vasselin | 74 | 3 | |
 Brazil | Rafael Matos | Spain | David Vega Hernández | 76 | 4 |
The following pairs received wildcards into the doubles main draw:
Simone Bolelli / Fabio Fognini → replaced by Sander Gillé / Joran Vliegen