| Date: | 7–13 March |
| Edition: | 12th |
| Surface: | Hard |
| Location: | Monterrey, Mexico |
| Champs: |  Fernando Verdasco |
| Champd: |  Hans Hach Verdugo /  Austin Krajicek |
| Before Year: | 2020 |
The 2022 Monterrey Challenger was a professional tennis tournament played on hard courts. It was the twelfth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Monterrey, Mexico from 7 to 13 March 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Spain | Fernando Verdasco | 153 | 1 | |
 United Kingdom | Jay Clarke | 173 | 2 | |
| Jason Jung | 218 | 3 | ||
| Cedrik-Marcel Stebe | 222 | 4 | ||
 Argentina | Juan Pablo Ficovich | 227 | 5 | |
 France | Maxime Janvier | 239 | 6 | |
 India | Prajnesh Gunneswaran | 246 | 7 | |
| France | Geoffrey Blancaneaux | 247 | 8 |
The following players received wildcards into the singles main draw:
Milledge Cossu Ryan Harrison Alex HernándezThe following players received entry into the singles main draw using protected rankings:
The following players received entry from the qualifying draw:
See main article: 2022 Monterrey Challenger – Singles.
Fernando Verdasco def. Prajnesh Gunneswaran 4–6, 6–3, 7–6(7–3).See main article: 2022 Monterrey Challenger – Doubles.
Hans Hach Verdugo / Austin Krajicek def. Robert Galloway / 
John-Patrick Smith 6–0, 6–3.
