| Champ: |  Carlos Alcaraz |
| Runner: |  Casper Ruud |
| Score: | 7–5, 6–4 |
| Draw: | 96 (12 / 5) |
| Seeds: | 32 |
| Before Year: | 2021 |
See main article: article and 2022 Miami Open.
Carlos Alcaraz defeated Casper Ruud in the final, 7–5, 6–4 to win the men's singles tennis title at the 2022 Miami Open. It was his first Masters 1000 title, and he became the first Spaniard to win the title. The victory also made Alcaraz, at 18 years and 333 days old, the youngest men's singles titlist in Miami Open history (breaking Novak Djokovic's record set in 2007), and the youngest Masters 1000 champion since Rafael Nadal at the 2005 Monte Carlo Masters.[1] Ruud became the first Norwegian to reach a Masters 1000 final, and the first Scandinavian since Robin Söderling at the 2010 Paris Masters.[2]
Hubert Hurkacz was the defending champion,[3] but lost in the semifinals to Alcaraz.[4]
By reaching the semifinals on his Masters 1000 debut, Francisco Cerúndolo became the first player to achieve the feat since Jerzy Janowicz at the 2012 Paris Masters. Ranked No. 103, Cerúndolo was also the lowest-ranked semifinalist in tournament history.
Novak Djokovic and Daniil Medvedev were in contention for the ATP No. 1 singles ranking.[5] Djokovic retained the top ranking when Medvedev lost in the quarterfinals to Hurkacz.[6]
At the time, this tournament marked the final professional appearance of former world No. 5 and two-time major finalist Kevin Anderson, who lost in the second round to Juan Manuel Cerúndolo.[7] Anderson returned to professional tennis 14 months later at the 2023 Hall of Fame Open.
All seeds received a bye into the second round.[8]
The following are the seeded players. Seedings are based on ATP rankings as of March 21, 2022. Rankings and points before are as of March 21, 2022.
As a result of special ranking adjustment rules due to the COVID-19 pandemic, players are defending the higher of (i) their points from the 2021 tournament or (ii) the remaining 50% of their points from the 2019 tournament. Those points were not mandatory and are included in the table below only if they counted towards the player's ranking as of March 21, 2022. Players who are not defending points from the 2021 or 2019 tournaments will instead have their 19th best result replaced by their points from the 2022 tournament.
| Seed | Rank | Player | Points before | Points defending (or 19th best result)† | Points won | Points after | Status | |
|---|---|---|---|---|---|---|---|---|
| 1 | 2 | Daniil Medvedev | 8,410 | 180 | 180 | 8,410 | Quarterfinals lost to  Hubert Hurkacz [8] | |
| 2 | 4 | Alexander Zverev | 7,025 | 10 | 180 | 7,195 | Quarterfinals lost to Casper Ruud [6] | |
| 3 | 5 | Stefanos Tsitsipas | 6,070 | 180 | 90 | 5,980 | Fourth round lost to Carlos Alcaraz [14] | |
| 4 | 6 |  Matteo Berrettini | 4,955 | (10) | 0 | 4,945 | Withdrew due to right hand injury | |
| 5 | 7 | Andrey Rublev | 4,725 | 360 | 10 | 4,375 | Second round lost to  Nick Kyrgios [WC] | |
| 6 | 8 | Casper Ruud | 3,870 | (90) | 600 | 4,380 | Runner-up, lost to Carlos Alcaraz [14] | |
| 7 | 9 |  Félix Auger-Aliassime | 3,803 | 188 | 10 | 3,625 | ||
| 8 | 10 | Hubert Hurkacz | 3,513 | 1,000 | 360 | 2,873 | Semifinals lost to Carlos Alcaraz [14] | |
| 9 | 11 | Jannik Sinner | 3,474 | 600 | 180 | 3,054 | Quarterfinals retired against  Francisco Cerúndolo | |
| 10 | 12 |  Cameron Norrie | 3,395 | 45 | 90 | 3,440 | Fourth round lost to Casper Ruud [6] | |
| 11 | 13 |  Taylor Fritz | 2,920 | 90 | 90 | 2,920 | ||
| 12 | 14 | Denis Shapovalov | 2,863 | 180 | 10 | 2,693 | Second round lost to Lloyd Harris | |
| 13 | 15 | Diego Schwartzman | 2,660 | 90 | 10 | 2,580 | Second round lost to Thanasi Kokkinakis [Q] | |
| 14 | 16 | Carlos Alcaraz | 2,414 | (3) | 1000 | 3,411 | Champion, defeated Casper Ruud [6] | |
| 15 | 17 | Roberto Bautista Agut | 2,375 | 360 | 45 | 2,060 | ||
| 16 | 18 | Reilly Opelka | 2,246 | 31 | 10 | 2,225 | Second round retired against Francisco Cerúndolo | |
| 17 | 19 | Pablo Carreño Busta | 2,220 | (10) | 45 | 2,255 | Third round lost to Jannik Sinner [9] | |
| 18 | 20 |  Nikoloz Basilashvili | 1,916 | 45 | 10 | 1,881 | ||
| 19 | 21 | Lorenzo Sonego | 1,902 | 90 | 10 | 1,822 | Second round lost to Denis Kudla [Q] | |
| 20 | 22 | John Isner | 1,846 | 300 | 10 | 1,556 | Second round lost to  Hugo Gaston | |
| 21 | 23 | Marin Čilić | 1,785 | 90 | 45 | 1,740 | Third round lost to Carlos Alcaraz [14] | |
| 22 | 24 | Gaël Monfils | 1,723 | (0) | 45 | 1,768 | Third round lost to Francisco Cerúndolo | |
| 23 | 25 | Karen Khachanov | 1,623 | 45 | 10 | 1,588 | ||
| 24 | 27 | Daniel Evans | 1,567 | (20) | 10 | 1,557 | Second round lost to  Yoshihito Nishioka [Q] | |
| 25 | 28 | Alex de Minaur | 1,531 | (10) | 45 | 1,566 | Third round lost to Stefanos Tsitsipas [3] | |
| 26 | 29 | Grigor Dimitrov | 1,471 | 23 | 10 | 1,458 | ||
| 27 | 30 | Cristian Garín | 1,466 | (23) | 10 | 1,453 | ||
| 28 | 31 | Frances Tiafoe | 1,453 | 90 | 90 | 1,453 | Fourth round lost to Francisco Cerúndolo | |
| 29 | 32 | Aslan Karatsev | 1,428 | 45 | 45 | 1,428 | Third round lost to Hubert Hurkacz [8] | |
| 30 | 33 |  Alexander Bublik | 1,416 | 180+63‡ | 45+20 | 1,238 | Third round lost to Casper Ruud [6] | |
| 31 | 34 | Fabio Fognini | 1,339 | 23 | 45 | 1,361 | Third round lost to Nick Kyrgios [WC] | |
| 32 | 35 | Albert Ramos Viñolas | 1,314 | 23 | 10 | 1,301 | Second round lost to Sebastian Korda |
The following players would have been seeded, but withdrew before the tournament began.
| Rank | Player | Points before | Points defending | Points after | Withdrawal reason | |
|---|---|---|---|---|---|---|
| 1 |  Novak Djokovic | 8,465 | 45 | 8,420 | Failure to meet vaccine requirements[9] | |
| 3 | Rafael Nadal | 7,115 | 0 | 7,115 | Schedule change | |
| 26 | Roger Federer | 1,620 | 500 | 1,120 | Right knee surgery |
Source:[10]