| Date: | 4–10 April |
| Edition: | 1st |
| Surface: | Clay |
| Location: | Mexico City, Mexico |
| Champs: | Marc-Andrea Hüsler |
| Champd: | Nicolás Jarry /  Matheus Pucinelli de Almeida |
| Main Name: | Mexico City Open (tennis) Mexico City Open |
The 2022 Mexico City Open was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Mexico City, Mexico between 4 and 10 April 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Argentina | Facundo Bagnis | 104 | 1 | |
| Argentina | Tomás Martín Etcheverry | 108 | 2 | |
 United States | Stefan Kozlov | 120 | 3 | |
 Slovakia | Andrej Martin | 128 | 4 | |
| Argentina | Juan Ignacio Londero | 130 | 5 | |
| United States | Ernesto Escobedo | 133 | 6 | |
| Nicolás Jarry | 142 | 7 | ||
 United Kingdom | Jay Clarke | 168 | 8 |
The following players received wildcards into the singles main draw:
Luis Carlos Álvarez Alex HernándezThe following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Mateus Alves
Nicolás Barrientos Nick Chappell Gilbert Klier Júnior Keegan SmithSee main article: 2022 Mexico City Open – Singles.
Tomás Martín Etcheverry 6–4, 6–2.See main article: 2022 Mexico City Open – Doubles.
Matheus Pucinelli de Almeida def. 
Jonathan Eysseric / 
Artem Sitak 6–2, 6–3.
