| Date: | 7–13 November |
| Edition: | 1st |
| Surface: | Hard |
| Location: | Matsuyama, Japan |
| Category: | ATP Challenger 80 |
| Champs: |  Hong Seong-chan |
| Champd: |  Andrew Harris / John-Patrick Smith |
The 2022 Matsuyama Challenger was a professional tennis tournament played on hard courts. It was the 1st edition of the tournament, which was part of the 2022 ATP Challenger Tour. It took place in Matsuyama, Japan, between 7 and 13 November 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Australia | ||||
| Australia | Rinky Hijikata | 159 | 2 | |
| Australia | ||||
 Japan | Kaichi Uchida | 172 | 4 | |
 France | Benoît Paire | 173 | 5 | |
 Bosnia and Herzegovina | Damir Džumhur | 179 | 6 | |
| Australia | Li Tu | 197 | 7 | |
| Japan | Rio Noguchi | 202 | 8 |
The following players received wildcards into the singles main draw:
Sho Katayama Yusuke Kusuhara Shintaro MochizukiThe following player received entry into the singles main draw using a protected ranking:
The following player received entry into the singles main draw as a special exempt:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
Hong Seong-chan
Ergi Kırkın Koki Matsuda
Mukund Sasikumar Shuichi SekiguchiThe following players received entry as lucky losers:
See main article: 2022 Matsuyama Challenger – Singles.
Hong Seong-chan def. Wu Tung-lin 6–3, 6–2.See main article: 2022 Matsuyama Challenger – Doubles.
Andrew Harris / John-Patrick Smith def. Toshihide Matsui / Kaito Uesugi 6–3, 4–6, [10–8].