See main article: article and 2022 Los Cabos Open.
Daniil Medvedev defeated the defending champion Cameron Norrie in the final, 7–5, 6–0 to win the singles tennis title.[1] It was his 14th career ATP Tour title, his first of the season, and his first since the 2021 US Open eleven months earlier.
The top four seeds receive a bye into the second round.