| Date: | 26 September–2 October |
| Edition: | 6th (men) 2nd (women) |
| Surface: | Clay |
| Location: | Lisbon, Portugal |
| Category: | ATP Challenger Tour ITF Women's World Tennis Tour |
| Champms: |  Marco Cecchinato |
| Champws: |  Carole Monnet |
| Champmd: |  Zdeněk Kolář / Gonçalo Oliveira |
| Champwd: | Francisca Jorge / Matilde Jorge |
The 2022 Lisboa Belém Open was a professional tennis tournament played on outdoor clay courts. It was the sixth (men) and second (women) editions of the tournament which were part of the 2022 ATP Challenger Tour and the 2022 ITF Women's World Tennis Tour. It took place in Lisbon, Portugal between 26 September and 2 October 2022.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Argentina | Pedro Cachin | 57 | 1 | |
 Spain | Carlos Taberner | 121 | 2 | |
| Italy | Francesco Passaro | 127 | 3 | |
 Austria | Filip Misolic | 145 | 4 | |
| Italy | Marco Cecchinato | 147 | 5 | |
| Italy | Franco Agamenone | 148 | 6 | |
| France | Alexandre Müller | 149 | 7 | |
| France | Manuel Guinard | 152 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as a special exempt:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Javier Barranco Cosano Oriol Roca Batalla Luca Van AsscheThe following player received entry as a lucky loser:
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Joanne Züger | 170 | 1 | ||
| France | Séléna Janicijevic | 191 | 2 | |
| Spain | Andrea Lázaro García | 232 | 3 | |
| Spain | Irene Burillo Escorihuela | 258 | 4 | |
 United States | Francesca Di Lorenzo | 261 | 5 | |
| France | Carole Monnet | 264 | 6 | |
| Francisca Jorge | 302 | 7 | ||
 Turkey | Çağla Büyükakçay | 310 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Enola Chiesa Marta González Encinas Giorgia Pinto Caroline Roméo Gaia Squarcialupi
Sevil Yuldasheva
Aleksandra ZuchańskaSee main article: 2022 Lisboa Belém Open – Men's singles.
Marco Cecchinato def. Luca Van Assche 6–3, 6–3. Carole Monnet def. Joanne Züger 1–6, 6–3, 6–2See main article: 2022 Lisboa Belém Open – Men's doubles.
Zdeněk Kolář / Gonçalo Oliveira def. 
Vladyslav Manafov / Oleg Prihodko 6–1, 7–6(7–4). Irene Burillo Escorihuela / Andrea Lázaro García, 6–2, 6–2
