| Date: | 24–30 October |
| Edition: | 18th |
| Surface: | Clay |
| Location: | Lima, Peru |
| Champs: | Daniel Altmaier |
| Champd: | Jesper de Jong / Max Houkes |
| Before Name: | Lima Challenger |
| Before Year: | 2022 |
| Main Name: | Lima Challenger |
| After Name: | Lima Challenger |
The 2022 Lima Challenger II was a professional tennis tournament played on clay courts. It was the 18th edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Lima, Peru between 24 and 30 October 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Argentina | Federico Coria | 71 | 1 | |
| Argentina | Tomás Martín Etcheverry | 87 | 2 | |
 Italy | Marco Cecchinato | 98 | 3 | |
| Daniel Altmaier | 103 | 4 | ||
 Peru | Juan Pablo Varillas | 123 | 5 | |
| Argentina | Camilo Ugo Carabelli | 126 | 6 | |
| Argentina | ||||
 Kazakhstan | Timofey Skatov | 158 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as a special exempt:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
Jan Choinski
Nikola Milojević
Giovanni Mpetshi Perricard Genaro Alberto Olivieri
Thiago Seyboth WildThe following players received entry as lucky losers:
See main article: article and 2022 Lima Challenger II – Singles.
Tomás Martín Etcheverry 6–1, 6–7(4–7), 6–4.See main article: article and 2022 Lima Challenger II – Doubles.
Guido Andreozzi / Guillermo Durán 7–6(8–6), 3–6, [12–10].