| Date: | 1–7 August 2022 |
| Edition: | 27th (men) 25th (women) |
| Surface: | Hard / Outdoor |
| Location: | Lexington, Kentucky, United States |
| Category: | ATP Challenger Tour ITF Women's World Tennis Tour |
| Prize Money: | $53,120 (men) $60,000 (women) |
| Champms: |  Shang Juncheng |
| Champmd: |  Yuki Bhambri / Saketh Myneni |
| Champws: |  Katie Swan |
| Champwd: | Aldila Sutjiadi /  Kateryna Volodko |
| Before Name: | Kentucky Bank Tennis Championships |
The 2022 Lexington Challenger was a professional tennis tournament played on outdoor hard courts. It was the twenty-seventh edition of the tournament which was part of the 2022 ATP Challenger Tour, and the twenty-fifth edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Lexington, Kentucky, United States between 1 and 7 August 2022.[1]
See main article: 2022 Lexington Challenger – Men's singles.
Shang Juncheng def. 
Emilio Gómez 6–4, 6–4.See main article: 2022 Lexington Challenger – Men's doubles.
Yuki Bhambri / Saketh Myneni def. Gijs Brouwer / Aidan McHugh 3–6, 6–4, [10–8].See main article: 2022 Lexington Challenger – Women's singles.
Katie Swan def. Jodie Burrage, 6–0, 3–6, 6–3See main article: 2022 Lexington Challenger – Women's doubles.
Kateryna Volodko def. 
Jada Hart / Dalayna Hewitt, 7–5, 6–3| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Roman Safiullin | 119 | 1 | ||
| Ecuador | Emilio Gómez | 146 | 2 | |
 Czech Republic | Dalibor Svrčina | 169 | 3 | |
| Gijs Brouwer | 195 | 4 | ||
 Kazakhstan | Mikhail Kukushkin | 207 | 5 | |
 Argentina | Genaro Alberto Olivieri | 226 | 6 | |
| United States | Aleksandar Kovacevic | 227 | 7 | |
 France | Enzo Couacaud | 230 | 8 |
The following players received a wildcard into the singles main draw:
Millen Hurrion Aleksandar Kovacevic Evan ZhuThe following player received entry into the singles main draw using a protected ranking:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Alafia Ayeni Gage Brymer Stefan Dostanic Ryan Harrison Cannon Kingsley Strong KirchheimerThe following player received entry as a lucky loser:
Kyle Seelig| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Japan | Moyuka Uchijima | 130 | 1 | |
| United Kingdom | Jodie Burrage | 144 | 2 | |
| France | Tessah Andrianjafitrimo | 173 | 3 | |
 Australia | Priscilla Hon | 197 | 4 | |
| Australia | Seone Mendez | 199 | 5 | |
 Israel | Lina Glushko | 220 | 6 | |
| Australia | Lizette Cabrera | 226 | 7 | |
| United Kingdom | Katie Swan | 227 | 8 |
The following players received wildcards into the singles main draw:
Samantha Crawford Qavia Lopez Madison SiegThe following players received entry from the qualifying draw:
Jessie Aney Dalayna Hewitt Taylor Ng Erica Oosterhout Adriana Reami Peyton Stearns