See main article: 2022 Ladies Open Lausanne.
Petra Martić defeated Olga Danilović in the final, 6–4, 6–2 to win the singles tennis title at the 2022 Ladies Open Lausanne. It was Martić's first WTA title since Istanbul in 2019.
Tamara Zidanšek was the defending champion, but was defeated in the first round by Anna Kalinskaya.[1]