See main article: article and 2022 Kuchyně Gorenje Prague Open.
Magdalena Fręch was the defending champion,[1] but chose to compete at the US Open instead.
Réka Luca Jani won the title, defeating Noma Noha Akugue in the final, 6–3, 7–6(7–4).
All seeds receive a bye into the second round.