| Date: | 31 October – 6 November (men's) 7 – 13 November (women's) |
| Edition: | 15th (men's) 5th (women's) |
| Category: | ATP Challenger Tour ITF Women's World Tennis Tour |
| Surface: | Hard |
| Location: | Yokohama, Japan |
| Champms: |  Christopher O'Connell |
| Champmd: |  Victor Vlad Cornea / Ruben Gonzales |
| Champws: |  Han Na-lae |
| Champwd: |  Saki Imamura / Naho Sato |
| Before Year: | 2019 |
The 2022 Keio Challenger was a professional tennis tournament played on hard courts. It was the 15th (men's) and 5th (women's) editions of the tournament and part of the 2022 ATP Challenger Tour and the 2022 ITF Women's World Tennis Tour. It took place in Yokohama, Japan between 31 October and 13 November 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Australia | Christopher O'Connell | 100 | 1 | |
| Australia | John Millman | 142 | 2 | |
| Japan | Kaichi Uchida | 168 | 3 | |
 Bosnia and Herzegovina | Damir Džumhur | 180 | 4 | |
| Wu Tung-lin | 207 | 5 | ||
| Japan | Hiroki Moriya | 213 | 6 | |
| Japan | Yosuke Watanuki | 223 | 7 | |
 Czech Republic | Zdeněk Kolář | 235 | 8 |
The following players received wildcards into the singles main draw:
Tomoya Fujiwara Shinji Hazawa Masamichi ImamuraThe following players received entry into the singles main draw using protected rankings:
The following players received entry from the qualifying draw:
Hong Seong-chan Taisei Ichikawa Yuki Mochizuki
Jonathan Mridha Ryota Tanuma James TrotterThe following player received entry as a lucky loser:
Rimpei Kawakami| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Korea, Republic of | Han Na-lae | 185 | 1 | |
| Japan | ||||
| Japan | Kyōka Okamura | 304 | 3 | |
| Japan | Himeno Sakatsume | 305 | 4 | |
| Japan | Sakura Hosogi | 316 | 5 | |
 Thailand | Luksika Kumkhum | 330 | 6 | |
| Japan | Haruka Kaji | 337 | 7 | |
| Japan | Chihiro Muramatsu | 348 | 8 |
The following players received wildcards into the singles main draw:
Anri Nagata Remika Ohashi Suzuho Oshino Karen TsutsumiThe following player received entry into the singles main draw using a protected ranking:
The following players received entry from the qualifying draw:
Erina Hayashi Aoi Ito Miyu Kato Natsumi Kawaguchi Honoka Kobayashi Michika Ozeki Himari Sato Eri ShimizuThe following players received entry as a lucky loser:
Yuka HosokiSee main article: article and 2022 Keio Challenger – Men's singles.
Christopher O'Connell def. Yosuke Watanuki 6–1, 6–7(5–7), 6–3. Han Na-lae def. Miyu Kato, 7–5, 6–0See main article: article and 2022 Keio Challenger – Men's doubles.
Victor Vlad Cornea / Ruben Gonzales def. Tomoya Fujiwara / Masamichi Imamura 7–5, 6–3. Saki Imamura / Naho Sato def. Han Na-lae / Mai Hontama, 6–4, 4–6, [10–5]