See main article: 2022 Karlsruhe Open.
Mayar Sherif and Panna Udvardy won the title, defeating Yana Sizikova and Alison Van Uytvanck in the final, 5–7, 6–4, [10–2].[1]
Irina Bara and Ekaterine Gorgodze were the defending champions, but chose not to participate.[2]