| Date: | 10 – 15 May |
| Edition: | 3rd |
| Draw: | 32S / 8D |
| Category: | WTA 125 |
| Location: | Karlsruhe, Germany |
| Venue: | TC Rüppurr |
| Surface: | Clay |
| Prize Money: | $115,000 |
| Champs: |  Mayar Sherif |
| Champd: | Mayar Sherif /  Panna Udvardy |
The 2022 Karlsruhe Open (also known as the Liqui Moly Open for sponsorship reasons) was a professional tennis tournament played on outdoor clay courts. It was the 3rd edition of the tournament and part of the 2022 WTA 125 tournaments, offering a total of $115,000 in prize money. It took place in Karlsruhe, Germany between 10 and 15 May 2022.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Belgium | Alison Van Uytvanck | 59 | 1 | |
| Egypt | Mayar Sherif | 61 | 2 | |
| Hungary | Anna Bondár | 68 | 3 | |
| Belgium | Greet Minnen | 79 | 4 | |
| Hungary | Panna Udvardy | 83 | 5 | |
 France | Clara Burel | 84 | 6 | |
| Hungary | Dalma Gálfi | 91 | 7 | |
 United States | Bernarda Pera | 100 | 8 |
The following players received a wildcard into the singles main draw:
The following players received entry into the singles main draw throughprotected ranking:
Irina Bara → replaced by Bibiane Schoofs
Harriet Dart → replaced by 
Katarzyna Kawa
Kathinka von Deichmann| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Poland | Katarzyna Piter | Belgium | Kimberley Zimmermann | 157 | 1 | |
 Slovakia | Tereza Mihalíková | Belgium | Greet Minnen | 158 | 2 |
The following pair received a wildcard into the doubles main draw:
See main article: 2022 Karlsruhe Open – Singles.
Mayar Sherif def. Bernarda Pera 6–2, 6–4See main article: 2022 Karlsruhe Open – Doubles.
Mayar Sherif / Panna Udvardy def. Yana Sizikova / Alison Van Uytvanck 5–7, 6–4, [10–2]