See main article: article and 2022 Italian Open (tennis).
Veronika Kudermetova and Anastasia Pavlyuchenkova defeated reigning champion Giuliana Olmos and partner Gabriela Dabrowski in the final, 1–6, 6–4, [10–7] to win the women's doubles tennis title at the 2022 Italian Open.
Sharon Fichman and Olmos were the defending champions,[1] but Fichman could not defend her title due to injury.
The following are the seeded teams, based on WTA rankings as of April 25, 2022.
| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Storm Sanders | Zhang Shuai | 22 | 1 | |||
| Gabriela Dabrowski | Giuliana Olmos | 29 | 2 | |||
| Desirae Krawczyk | Demi Schuurs | 33 | 3 | |||
| Alexa Guarachi | Andreja Klepač | 35 | 4 | |||
| Coco Gauff | Jessica Pegula | 41 | 5 | |||
| Lucie Hradecká | Sania Mirza | 50 | 6 | |||
| Xu Yifan | Yang Zhaoxuan | 59 | 7 | |||
 Japan | Shuko Aoyama | Chan Hao-ching | 61 | 8 |
Irina-Camelia Begu / 
Shelby Rogers → replaced by 
Nadiia Kichenok / Shelby Rogers Lyudmyla Kichenok / Jeļena Ostapenko → replaced by Ekaterina Alexandrova / 
Anna Danilina Nadiia Kichenok / Raluca Olaru → replaced by 
Kirsten Flipkens / 
Sara Sorribes Tormo Elise Mertens → replaced by Marta Kostyuk / Elena-Gabriela Ruse
Tereza Martincová / Aliaksandra Sasnovich → replaced by Madison Brengle / 
Arina Rodionova