| Date: | 25–31 July 2022 (women) 1–7 August 2022 (men) |
| Edition: | 19th (men) 7th (women) |
| Surface: | Clay / Outdoor |
| Location: | Cordenons, Italy |
| Category: | ATP Challenger Tour ITF Women's World Tennis Tour |
| Prize Money: | €45,730 (men) $60,000 (women) |
| Champms: |  Zhang Zhizhen |
| Champmd: |  Dustin Brown /  Andrea Vavassori |
| Champws: |  Panna Udvardy |
| Champwd: | Angelica Moratelli / Eva Vedder |
The 2022 Serena Wines 1881 Tennis Cup Internazionali di Tennis del Friuli Venezia Giulia was a professional tennis tournament played on outdoor clay courts. It was the nineteenth edition of the tournament which was part of the 2022 ATP Challenger Tour, and the seventh edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Cordenons, Italy between 25 July and 7 August 2022.[1]
See main article: 2022 Internazionali di Tennis del Friuli Venezia Giulia – Men's singles.
Zhang Zhizhen def. Andrea Vavassori 2–6, 7–6(7–5), 6–3.See main article: 2022 Internazionali di Tennis del Friuli Venezia Giulia – Men's doubles.
Dustin Brown / Andrea Vavassori def. 
Ivan Sabanov / Matej Sabanov 6–4, 7–5.See main article: 2022 Internazionali di Tennis del Friuli Venezia Giulia – Women's singles.
Panna Udvardy def. Elina Avanesyan, 6–2, 6–0See main article: 2022 Internazionali di Tennis del Friuli Venezia Giulia – Women's doubles.
Angelica Moratelli / Eva Vedder def. 
Yuliana Lizarazo / Aurora Zantedeschi, 6–3, 6–2.| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Serbia | Laslo Đere | 77 | 1 | |
 Argentina | Juan Manuel Cerúndolo | 107 | 2 | |
| Argentina | Camilo Ugo Carabelli | 118 | 3 | |
| Pavel Kotov | 122 | 4 | ||
| Italy | Flavio Cobolli | 133 | 5 | |
 Czech Republic | Zdeněk Kolář | 134 | 6 | |
 France | Alexandre Müller | 149 | 7 | |
| Italy | Marco Cecchinato | 151 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as special exempts:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Mattia Bellucci
Kimmer Coppejans Giacomo Dambrosi
Viktor Durasovic
Nicolas Moreno de AlboranThe following player received entry as a lucky loser:
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Hungary | Panna Udvardy | 108 | 1 | |
| Elina Avanesyan | 129 | 2 | ||
 Austria | Julia Grabher | 145 | 3 | |
| Czech Republic | Linda Fruhvirtová | 153 | 4 | |
 Spain | Marina Bassols Ribera | 211 | 5 | |
| Italy | ||||
| Katharina Gerlach | 223 | 7 | ||
 Japan | Kurumi Nara | 237 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as a special exempt:
Anna TuratiThe following players received entry from the qualifying draw:
Federica Arcidiacono
Bianca Behúlová Nuria Brancaccio Angelica Moratelli Julia Riera Bianca TuratiThe following players received as lucky losers:
Timea Jarušková Arianna Zucchini