| Date: | 18 – 24 July |
| Edition: | 3rd |
| Surface: | Clay |
| Location: | Trieste, Italy |
| Champs: |  Francesco Passaro |
| Champd: |  Diego Hidalgo /  Cristian Rodríguez |
The 2022 Internazionali di Tennis Città di Trieste was a professional tennis tournament played on clay courts. It was the 3rd edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Trieste, Italy between 18 and 24 July 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Slovakia | Norbert Gombos | 112 | 1 | |
| Italy | Franco Agamenone | 144 | 2 | |
| Italy | Gianluca Mager | 147 | 3 | |
 Austria | Dennis Novak | 153 | 4 | |
| Italy | Marco Cecchinato | 154 | 5 | |
 Serbia | Nikola Milojević | 156 | 6 | |
 Argentina | Santiago Rodríguez Taverna | 161 | 7 | |
 France | Alexandre Müller | 162 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as a special exempt:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Lukas Neumayer Giovanni Oradini Samuel Vincent Ruggeri
Zhang ZhizhenSee main article: 2022 Internazionali di Tennis Città di Trieste – Singles.
Francesco Passaro def. Zhang Zhizhen 4–6, 6–3, 6–3.See main article: 2022 Internazionali di Tennis Città di Trieste – Doubles.
Diego Hidalgo / Cristian Rodríguez def. Marco Bortolotti / 
Sergio Martos Gornés 4–6, 6–3, [10–5].