The 2022 Internazionali Femminili di Palermo was a professional women's tennis tournament played on outdoor clay courts at the Country Time Club. It was the 30th edition of the tournament and part of the 2022 WTA Tour. It took place in Palermo, Italy, between 18 and 24 July 2022.[1]
See main article: 2022 Internazionali Femminili di Palermo – Singles.
Irina-Camelia Begu def. 
Lucia Bronzetti 6–2, 6–2This was Begu's first title of the year and fifth of her career.
See main article: 2022 Internazionali Femminili di Palermo – Doubles.
Anna Bondár / 
Kimberley Zimmermann def. Amina Anshba / Panna Udvardy 6–3, 6–2.| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Italy | ||||
 Kazakhstan | Yulia Putintseva | 32 | 2 | |
 China | Zhang Shuai | 37 | 3 | |
 Spain | Sara Sorribes Tormo | 43 | 4 | |
| Caroline Garcia | 48 | 5 | ||
| Romania | Irina-Camelia Begu | 49 | 6 | |
| Hungary | Anna Bondár | 53 | 7 | |
| Spain | Nuria Párrizas Díaz | 54 | 8 |
The following players received wildcards into the main draw:
The following player received entry using a protected ranking:
The following players received entry from the qualifying draw:
Marina Bassols Ribera
Léolia Jeanjean Rebeka Masarova
Asia Muhammad Matilde PaolettiThe following player received entry as a lucky loser:
Panna Udvardy
Danka Kovinić → replaced by Ylena In-Albon
Jaimee Fourlis Ana Bogdan
Julia Grabher Ajla Tomljanović → replaced by Chloé Paquet Martina Trevisan → replaced by 
Carolina Alves| Country | Player | Country | Player | Rank1 | Seed |
|---|---|---|---|---|---|
| Alexa Guarachi | United States | Asia Muhammad | 67 | 1 | |
| Kazakhstan | Anna Danilina |  Georgia | Oksana Kalashnikova | 103 | 2 |
| Hungary | Anna Bondár | Belgium | Kimberley Zimmermann | 119 | 3 |
| United States | Ingrid Neel |  Czech Republic | Renata Voráčová | 207 | 4 |
The following pairs received wildcards into the doubles main draw:
The following pair received entry into the doubles main draw using a special ranking:
The following pair received entry as alternates:
Natela Dzalamidze / Kaja Juvan → replaced by Natela Dzalamidze / Anastasia Tikhonova Ekaterine Gorgodze / Oksana Kalashnikova → replaced by Anna Danilina / Oksana Kalashnikova Zhang Shuai → replaced by Wang Xiyu / Zhang Shuai Elisabetta Cocciaretto / Camilla Rosatello → replaced by Jaimee Fourlis / Gabriela Lee