| Date: | 30 May–5 June 2022 |
| Edition: | 13th |
| Surface: | Clay / Outdoor |
| Location: | Brescia, Italy |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $60,000 |
| Champs: |  Ángela Fita Boluda |
| Champd: |  Nuria Brancaccio / Lisa Pigato |
| Before Year: | 2019 |
The 2022 Internazionali Femminili di Brescia was a professional tennis tournament played on outdoor clay courts. It was the thirteenth edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Brescia, Italy between 30 May and 5 June 2022.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Ylena In-Albon | 117 | 1 | ||
| Spain | Rebeka Masarova | 121 | 2 | |
 China | Yuan Yue | 144 | 3 | |
| Despina Papamichail | 170 | 5 | ||
| Stefanie Vögele | 186 | 6 | ||
| Italy | Sara Errani | 194 | 7 | |
The following players received wildcards into the singles main draw:
Gloria Ceschi Melania Delai Lisa Pigato Angelica RaggiThe following players received entry from the qualifying draw:
Sara Cakarevic Diletta Cherubini Ángela Fita Boluda Nicole Fossa Huergo
Yuliana Lizarazo
Jazmín Ortenzi Aurora ZantedeschiThe following players received entry as lucky losers:
See main article: 2022 Internazionali Femminili di Brescia – Singles.
Ángela Fita Boluda def. Despina Papamichail, 6–2, 6–0See main article: 2022 Internazionali Femminili di Brescia – Doubles.
Nuria Brancaccio / Lisa Pigato def. 
Zhibek Kulambayeva / Diāna Marcinkēviča, 6–4, 6–1