| Date: | 3–9 October |
| Edition: | 9th |
| Surface: | Hard (Indoor) |
| Location: | Mouilleron-le-Captif, France |
| Champs: | Jelle Sels |
| Champd: | Sander Arends / David Pel |
| After Name: | Open de Vendée |
The 2022 Internationaux de Tennis de Vendée was a professional tennis tournament played on hard courts. It was the ninth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Mouilleron-le-Captif, France between 3 and 9 October 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Czech Republic | Jiří Lehečka | 74 | 1 | |
 United States | J. J. Wolf | 75 | 2 | |
 France | Hugo Gaston | 81 | 3 | |
| France | Richard Gasquet | 83 | 4 | |
| France | ||||
| France | Hugo Grenier | 97 | 6 | |
 Slovakia | Norbert Gombos | 98 | 7 | |
| Czech Republic | Tomáš Macháč | 107 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
Mathias Bourgue Jurgen Briand Alexis Gautier Jules Marie David Poljak Valentin RoyerThe following player received entry as a lucky loser:
See main article: 2022 Internationaux de Tennis de Vendée – Singles.
Vasek Pospisil 6–4, 6–3.See main article: 2022 Internationaux de Tennis de Vendée – Doubles.
Purav Raja / Divij Sharan 6–7(1–7), 7–6(8–6), [10–6].