| Date: | 15–21 May |
| Edition: | 36th |
| Category: | WTA 250 |
| Draw: | 32S / 16D |
| Surface: | Clay |
| Location: | Strasbourg, France |
| Venue: | Tennis Club de Strasbourg |
| Prize Money: | $251,750 |
| Champs: | Angelique Kerber |
| Champd: |  Nicole Melichar-Martinez /  Daria Saville |
The 2022 Internationaux de Strasbourg was a professional tennis tournament played on outdoor clay courts in Strasbourg, France. It was the 36th edition of the tournament and part of the WTA 250 tournaments of the 2022 WTA Tour. It took place at the Tennis Club de Strasbourg between 15 and 21 May 2022.[1]
See main article: 2022 Internationaux de Strasbourg – Singles.
This is Kerber's first title of the year and 14th of her career.
See main article: 2022 Internationaux de Strasbourg – Doubles.
Nicole Melichar-Martinez / Daria Saville def. 
Lucie Hradecká / 
Sania Mirza, 5–7, 7–5, [10–6]| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Czech Republic | Karolína Plíšková | 6 | 1 | |
| Angelique Kerber | 19 | 2 | ||
 Romania | Sorana Cîrstea | 26 | 3 | |
 Belgium | Elise Mertens | 33 | 4 | |
 China | Zhang Shuai | 42 | 5 | |
| United States | Sloane Stephens | 49 | 6 | |
| Czech Republic | ||||
 Poland | Magda Linette | 54 | 8 | |
| Viktorija Golubic | 56 | 9 |
The following players received wildcards into the singles main draw:
The following player received entry using a protected ranking into the singles main draw:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
Madison Brengle → replaced by Ana Konjuh
Camila Giorgi → replaced by 
Nefisa Berberović
Anhelina Kalinina → replaced by Angelina Gabueva Barbora Krejčiková → replaced by Kaja Juvan Tereza Martincová → replaced by Yana Morderger
Harmony Tan Jasmine Paolini → replaced by 
Heather Watson Alison Riske → replaced by Bernarda Pera Shelby Rogers → replaced by Océane Dodin
Elena Rybakina → replaced by Diane Parry Kateřina Siniaková → replaced by Varvara Gracheva Maryna Zanevska Markéta Vondroušová → replaced by Fiona Ferro| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Czech Republic | Lucie Hradecká | India | Sania Mirza | 52 | 1 | |
 Japan | Shuko Aoyama | Chan Hao-ching | 54 | 2 | ||
| China | Xu Yifan | China | Yang Zhaoxuan | 69 | 3 | |
| Latisha Chan | Australia | Samantha Stosur | 79 | 4 |
The following pair received entry using a protected ranking:
Kirsten Flipkens / Nicole Melichar-Martinez → replaced by Nicole Melichar-Martinez / Daria Saville