| Date: | 18–24 July |
| Edition: | 1st |
| Surface: | Hard (indoor) |
| Location: | Indianapolis, United States |
| Champs: |  Wu Yibing |
| Champd: |  Hans Hach Verdugo /  Hunter Reese |
The 2022 Indy Challenger was a professional tennis tournament played on indoor hard courts. It was the first edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Indianapolis, United States between 18 and 24 July 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Peter Gojowczyk | 91 | 1 | ||
| Tim van Rijthoven | 103 | 2 | ||
| United States | Stefan Kozlov | 104 | 3 | |
| United States | J. J. Wolf | 111 | 4 | |
| Dominik Koepfer | 136 | 5 | ||
 United Kingdom | Liam Broady | 140 | 6 | |
| United States | Mitchell Krueger | 146 | 7 | |
| United States | Christopher Eubanks | 163 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry into the singles main draw as special exempts:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2022 Indy Challenger – Singles.
Wu Yibing def. Aleksandar Kovacevic 6–7(10–12), 7–6(15–13), 6–3.See main article: 2022 Indy Challenger – Doubles.
Hans Hach Verdugo / Hunter Reese def. 
Purav Raja / Divij Sharan 7–6(7–3), 3–6, [10–7].
