| Date: | 2–8 May 2022 |
| Edition: | 29th (men) 17th (women) |
| Surface: | Clay / Outdoor |
| Location: | Prague, Czech Republic |
| Category: | ATP Challenger Tour ITF Women's World Tennis Tour |
| Prize Money: | €45,730 (men) $60,000 (women) |
| Champms: |  Pedro Cachin |
| Champmd: | Nuno Borges / Francisco Cabral |
| Champws: |  Maja Chwalińska |
| Champwd: | Bárbara Gatica /  Rebeca Pereira |
| After Name: | Advantage Cars Prague Open |
The 2022 I.ČLTK Prague Open was a tournament played on outdoor clay. It was the 29th edition for men and 17th for women, which were respectively part of the 2022 ATP Challenger Tour and the 2022 ITF Women's World Tennis Tour. It took place in Prague, Czech Republic between 2 and 8 May 2022.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Australia | Aleksandar Vukic | 128 | 1 | |
| Nuno Borges | 131 | 2 | ||
 Czech Republic | ||||
| Czech Republic | Vít Kopřiva | 166 | 4 | |
| Argentina | Pedro Cachin | 171 | 5 | |
| Jesper de Jong | 177 | 6 | ||
| Argentina | Juan Pablo Ficovich | 181 | 7 | |
 Italy | Federico Gaio | 182 | 8 |
The following players received wildcards into the singles main draw:
Jonáš Forejtek Martin Krumich Andrew PaulsonThe following player received entry into the singles main draw using a protected ranking:
The following player received entry into the singles main draw as a special exempt:
The following player received entry into the singles main draw as an alternate:
The following players received entry from the qualifying draw:
Matteo Donati Daniel Michalski
Yshai Oliel Lukáš Rosol
Clément TaburThe following players received entry as lucky losers:
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Georgia | Ekaterine Gorgodze | 118 | 1 | |
 Hungary | Réka Luca Jani | 139 | 2 | |
 China | Yuan Yue | 142 | 3 | |
| Despina Papamichail | 172 | 4 | ||
 Slovakia | Rebecca Šramková | 179 | 5 | |
| Valentini Grammatikopoulou | 183 | 6 | ||
| Australia | Lizette Cabrera | 188 | 8 |
The following players received wildcards into the singles main draw:
Lucie Havlíčková Miriam Kolodziejová
Daria Lopatetska Barbora PalicováThe following player received entry using a protected ranking:
The following player received entry as a special exempt:
The following players received entry from the qualifying draw:
Anastasia Dețiuc
Nagi Hanatani Linda Klimovičová Aneta Laboutková
Andreea Prisăcariu Dominika Šalková
Natalija StevanovićThe following player received entry as a lucky loser:
See main article: 2022 I.ČLTK Prague Open – Men's singles.
Pedro Cachin def. Lorenzo Giustino 6–3, 7–6(7–4).See main article: 2022 I.ČLTK Prague Open – Men's doubles.
Andrew Paulson / Adam Pavlásek 6–4, 6–7(3–7), [10–5].See main article: 2022 I.ČLTK Prague Open – Women's singles.
Maja Chwalińska def. Ekaterine Gorgodze, 7–5, 6–3See main article: 2022 I.ČLTK Prague Open – Women's doubles.
Rebeca Pereira def. Miriam Kolodziejová / Jesika Malečková, 6–4, 6–2
