| Date: | 10–16 October 2022 |
| Edition: | 13th |
| Surface: | Hard / Outdoor |
| Location: | Las Vegas, United States |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $60,000 |
| Champs: |  Yuan Yue |
| Champd: |  Carmen Corley / Ivana Corley |
The 2022 Henderson Tennis Open was a professional tennis tournament played on outdoor hard courts. It was the thirteenth edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Las Vegas, United States between 10 and 16 October 2022.[1]
See main article: 2022 Henderson Tennis Open – Singles.
Yuan Yue def. Diana Shnaider, 4–6, 6–3, 6–1See main article: 2022 Henderson Tennis Open – Doubles.
Carmen Corley / Ivana Corley def. 
Katarina Kozarov / Veronica Miroshnichenko, 6–2, 6–0| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Hungary | Panna Udvardy | 81 | 1 | |
| China | Yuan Yue | 102 | 2 | |
 Sweden | Rebecca Peterson | 111 | 3 | |
| United States | Katie Volynets | 117 | 4 | |
| United States | Asia Muhammad | 162 | 5 | |
| United States | Katrina Scott | 184 | 6 | |
 Australia | Astra Sharma | 200 | 7 | |
 Argentina | Nadia Podoroska | 203 | 8 |
The following players received wildcards into the singles main draw:
Raveena Kingsley Rasheeda McAdoo Anna Rogers
Yanina WickmayerThe following players received entry from the qualifying draw:
Solymar Colling Carmen Corley Tori Kinard Katarina Kozarov Lisa Zaar