The 2022 Gwangju Open was a professional tennis tournament played on hard courts. It was the 5th edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Gwangju, South Korea between 3 and 9 October 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Ecuador | Emilio Gómez | 102 | 1 | |
 Australia | Christopher O'Connell | 105 | 2 | |
| Australia | John Millman | 108 | 3 | |
 United States | Christopher Eubanks | 131 | 4 | |
 China | Wu Yibing | 132 | 5 | |
 United Kingdom | Ryan Peniston | 140 | 6 | |
 Hungary | Zsombor Piros | 158 | 7 | |
| Maximilian Marterer | 160 | 8 |
The following players received wildcards into the singles main draw:
Hong Seong-chan Park Ui-sung Shin San-huiThe following player received entry into the singles main draw using a protected ranking:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2022 Gwangju Open – Singles.
Zsombor Piros def. Emilio Gómez 6–2, 6–4.See main article: 2022 Gwangju Open – Doubles.
Nicolás Barrientos / 
Miguel Ángel Reyes-Varela def. 
Yuki Bhambri / Saketh Myneni 2–6, 6–3, [10–6].