See main article: article and 2022 Guanajuato Open.
Paige Hourigan and Astra Sharma were the defending champions having won the previous edition in 2019,[1] however both players chose not to participate.
Kaitlyn Christian and Lidziya Marozava won the title, defeating Anastasia Tikhonova and Daniela Vismane in the final, 6–0, 6–2.