| Date: | 4–10 July |
| Edition: | 15th |
| Surface: | Clay |
| Venue: | Tennis Club de Contrexéville |
| Location: | Contrexéville, France |
| Category: | WTA 125 |
| Prize Money: | $115,000 |
| Champs: |  Sara Errani |
| Champd: |  Ulrikke Eikeri /  Tereza Mihalíková |
The 2022 Grand Est Open 88 was a professional women's tennis tournament played on outdoor clay courts. It was the fifteenth edition of the tournament and first ever as a WTA 125 event, which is also part of the 2022 WTA 125 tournaments. It took place in Contrexéville, France between 4 and 10 July 2022.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Hungary | Anna Bondár | 64 | 1 | |
| Varvara Gracheva | 69 | 2 | ||
| Italy | Jasmine Paolini | 72 | 3 | |
 France | Océane Dodin | 85 | 4 | |
| Arantxa Rus | 86 | 5 | ||
| Hungary | Dalma Gálfi | 89 | 6 | |
| Ylena In-Albon | 113 | 7 | ||
 United States | Katie Volynets | 117 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry using a protected ranking:
The following players received entry from the qualifying draw:
Tessah Andrianjafitrimo → replaced by 
Fernanda Contreras Gómez
Ana Bogdan → replaced by 
Olivia Gadecki Sara Errani Diane Parry → replaced by Elsa Jacquemot Harmony Tan → replaced by 
María Lourdes Carlé| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Norway | Ulrikke Eikeri | Slovakia | Tereza Mihalíková | 111 | 1 | |
 China | Han Xinyun | Alexandra Panova | 178 | 2 |
The following pair received a wildcard into the doubles main draw:
See main article: 2022 Grand Est Open 88 – Singles.
Sara Errani def. Dalma Gálfi 6–4, 1–6, 7–6(7–4)See main article: 2022 Grand Est Open 88 – Doubles.
Ulrikke Eikeri / Tereza Mihalíková def. Han Xinyun / Alexandra Panova 7–6(10–8), 6–2