| Date: | 7–13 February 2022 |
| Edition: | 12th |
| Surface: | Hard / Indoor |
| Location: | Grenoble, France |
| Category: | ITF Women's World Tennis Tour |
| Prize Money: | $60,000 |
| Champs: |  Katie Boulter |
| Champd: |  Yuriko Miyazaki /  Prarthana Thombare |
| Main Name: | Open de l'Isère |
The 2022 Engie Open de l'Isère was a professional tennis tournament played on indoor hard courts. It was the twelfth edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Grenoble, France between 7 and 13 February 2022.[1]
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Arantxa Rus | 64 | 1 | ||
 Italy | Martina Trevisan | 93 | 2 | |
 Belgium | Greet Minnen | 96 | 3 | |
 France | Chloé Paquet | 119 | 4 | |
 Ukraine | Daria Snigur | 141 | 5 | |
| United Kingdom | Katie Boulter | 153 | 6 | |
| Ylena In-Albon | 156 | 7 | ||
 Russian Federation | Anna Blinkova | 157 | 8 |
The following players received wildcards into the singles main draw:
Carole Monnet Amandine Monnot Mallaurie Noël Alice RobbeThe following player received entry using a protected ranking:
The following players received entry from the qualifying draw:
Alicia Barnett Ekaterina Makarova Chloé Noël Evita Ramirez Margaux RouvroySee main article: 2022 Engie Open de l'Isère – Singles.
Katie Boulter def. Anna Blinkova, 7–6(7–2), 6–7(6–8), 6–2See main article: 2022 Engie Open de l'Isère – Doubles.
Yuriko Miyazaki / Prarthana Thombare def. Alicia Barnett / Olivia Nicholls, 6–3, 6–3