| Year: | 2022 |
| Team: | Eastern Illinois Panthers |
| Sport: | football |
| Conference: | Ohio Valley Conference |
| Short Conf: | OVC |
| Record: | 2–9 |
| Conf Record: | 1–4 |
| Head Coach: | Chris Wilkerson |
| Hc Year: | 1st |
| Off Coach: | Joe Davis |
| Oc Year: | 1st |
| Def Coach: | Adam Gristick |
| Dc Year: | 1st |
| Stadium: | O'Brien Field |
The 2022 Eastern Illinois Panthers football team represented Eastern Illinois University as a member of the Ohio Valley Conference (OVC) during the 2022 NCAA Division I FCS football season. The Panthers were led by first-year head coach Chris Wilkerson and played home games at O'Brien Field in Charleston, Illinois.
The OVC released their preseason coaches' poll on July 19, 2022. The Panthers were picked to finish in second to last place.[1]
| 1 | UT Martin | 70 (10) |
| 2 | Southeast Missouri | 59 (3) |
| 3 | Murray State | 51 |
| 4 | Tennessee State | 46 (1) |
| 5 | Tennessee Tech | 29 |
| 6 | Eastern Illinois | 20 |
| 7 | Lindenwood | 19 |
The Panthers had six players selected to the preseason all-OVC team.[2]
Offense
Defense
Source:[3]
See also: 2022 Northern Illinois Huskies football team.
See also: 2022 Chattanooga Mocs football team.
See also: 2022 Illinois State Redbirds football team and Mid-America Classic.
See also: 2022 Murray State Racers football team.
See also: 2022 Northwestern State Demons football team.
See also: 2022 Lindenwood Lions football team.
See also: 2022 Tennessee State Tigers football team.
See also: 2022 Tennessee Tech Golden Eagles football team.
See also: 2022 McNeese State Cowboys football team.
See also: 2022 Southeast Missouri State Redhawks football team.
See also: 2022 UT Martin Skyhawks football team.