| Year: | 2022 |
| Team: | East Carolina Pirates |
| Sport: | football |
| Conference: | American Athletic Conference |
| Short Conf: | AAC |
| Record: | 8–5 |
| Conf Record: | 4–4 |
| Head Coach: | Mike Houston |
| Hc Year: | 4th |
| Off Coach: | Donnie Kirkpatrick |
| Oc Year: | 4th |
| Off Scheme: | Spread |
| Def Coach: | Blake Harrell |
| Dc Year: | 3rd |
| Def Scheme: | 3–4 or 4–2–5 |
| Stadium: | Dowdy-Ficklen Stadium |
| Champion: | Birmingham Bowl champion |
| Bowl: | Birmingham Bowl |
| Bowl Result: | W 53–29 vs. Coastal Carolina |
The 2022 East Carolina Pirates football team represented East Carolina University during the 2022 NCAA Division I FBS football season. The Pirates played their home games at Dowdy-Ficklen Stadium in Greenville, North Carolina, and competed as members of the American Athletic Conference. They were led by head coach Mike Houston, in his fourth season.
| Chance Bates | LB | Kennesaw State | |
| Kamarro Edmonds | RB | North Carolina | |
| Michael Edwards | LB | Georgia Southern | |
| Aapri Washington | CB | Buffalo | |
| Isaiah Winstead | WR | Toledo | |
| Jarett Garner | WR | Duke | |
| Justin Redd | IOL | Norfolk State | |
| Ben Johnson | OT | Marist | |
| Jaylen Johnson | WR | Georgia | |
| Jack Powers | EDGE | Nevada | |
| Alex Harper | LS | North Carolina Central | |
| Shaundre Mims | DL | Charleston Southern | |
| David Chapeau | P | Air Force | |
| Parker Moorer | OT | West Virginia |
| Tyree Saunders | WR | Alabama State | |
| Ray Rose | WR | Tennessee State | |
| Walter Simmons | QB | Bethune-Cookman | |
| J'Vian McCray | DL | Austin Peay | |
| Cruz Temple | S | Arkansas State | |
| Jacob Coleman | TE | Middle Tennessee State | |
| Troy Lewis | WR | James Madison | |
| Jayden Chalmers | CB | Campbell | |
| TJ Lockley | WR | Jacksonville State | |
| David Laney | S | North Carolina A&T | |
| Nolan Johnson | CB | Miami (OH) | |
| Dre Terry | EDGE | Alabama A&M | |
| Traveon Freshwater | DL | Elizabeth City State | |
| Slade Roy | LS | LSU | |
| Nasir Clerk | CB | Delaware State | |
| Trent Holler | OL | Marshall | |
| Jaquaez Powell | OL | None | |
| Asa Barnes | RB | None | |
| Henry Garrison | DL | None | |
| Bryan Gragg | TE | None | |
| Wistar Allen | LB | None |
See main article: 2022 college football recruiting class. East Carolina signed 18 players in the class of 2022. The Pirates' recruiting class ranks 86th by 247Sports, 91st by On3, and 79th by Rivals.
See also: American football positions, Glossary of American football and Recruiting (college athletics).
The Pirates will host the three of their non-conference opponents, NC State from the ACC, Old Dominion from Conference USA and Campbell from Division I FCS. They will visit BYU from the FBS Independents[2]
See also: 2022 NC State Wolfpack football team and East Carolina–NC State rivalry.
See also: 2022 Old Dominion Monarchs football team.
See also: 2022 Campbell Fighting Camels football team.
See also: 2022 Navy Midshipmen football team.
See also: 2022 South Florida Bulls football team.
See also: 2022 Tulane Green Wave football team.
See also: 2022 Memphis Tigers football team and Homecoming.
See also: 2022 UCF Knights football team.
See also: 2022 BYU Cougars football team.
See also: 2022 Cincinnati Bearcats football team.
See also: 2022 Houston Cougars football team.
See also: 2022 Temple Owls football team.
See also: 2022 Coastal Carolina Chanticleers football team and 2022 Birmingham Bowl.