| Club: | Cruzeiro |
| Season: | 2022 |
| Manager: | Paulo Pezzolano |
| Owner: | Ronaldo |
| Chairman: | Sérgio Santos Rodrigues |
| Chrtitle: | President |
| Stadium: | Mineirão |
| Cup1: | Campeonato Mineiro |
| Cup1 Result: | Runners-up |
| League: | Série B |
| League Result: | 1st |
| Cup2: | Copa do Brasil |
| Cup2 Result: | Round of 16 |
| League Topscorer: | Edu (11) |
| Season Topscorer: | Edu (22) |
| Highest Attendance: | 61,291 vs CSA (6 November, Série B) |
| Lowest Attendance: | 7,413 vs URT (26 January, Campeonato Mineiro) |
| Average Attendance: | 41,042 |
| Largest Win: | 5–0 vs Sergipe (23 February, Copa do Brasil) |
| Largest Loss: | 0–3 vs Fluminense (12 July, Copa do Brasil) |
| Pattern La1: | _cruzeiro22h |
| Pattern B1: | _cruzeiro22h |
| Pattern Ra1: | _cruzeiro22h |
| Pattern Sh1: | _cruzeiro22h |
| Pattern So1: | _adidasbluel |
| Leftarm1: | 0000FF |
| Body1: | 0000FF |
| Rightarm1: | 0000FF |
| Shorts1: | FFFFFF |
| Socks1: | FFFFFF |
| Pattern La2: | _cruzeiro22a |
| Pattern B2: | _cruzeiro22a |
| Pattern Ra2: | _cruzeiro22a |
| Pattern Sh2: | _cruzeiro22a |
| Pattern So2: | _cruzeiro22al |
| Leftarm2: | FFFFFF |
| Body2: | FFFFFF |
| Rightarm2: | FFFFFF |
| Shorts2: | 0000CD |
| Socks2: | 0000CD |
| Pattern La3: | _cruzeiro21t |
| Pattern B3: | _cruzeiro21t |
| Pattern Ra3: | _cruzeiro21t |
| Pattern Sh3: | _cruzeiro21a |
| Pattern So3: | _adidaswhitel |
| Leftarm3: | 008000 |
| Body3: | 008000 |
| Rightarm3: | 008000 |
| Shorts3: | FFFFFF |
| Socks3: | FF0000 |
| American: | true |
| Prevseason: | 2021 |
| Nextseason: | 2023 |
The 2022 season was the 101st in the Cruzeiro Esporte Clube's existence.
Along with the Campeonato Brasileiro Série B, the club will also compete in the Campeonato Mineiro and in the Copa do Brasil.
See main article: 2022 Campeonato Mineiro.
See main article: 2022 Campeonato Brasileiro Série B.
See main article: 2022 Copa do Brasil.