| Main Name: | Charleston Open |
| Date: | April 4–10 |
| Edition: | 50th |
| Category: | WTA 500 |
| Draw: | 56S / 16D |
| Surface: | Green clay / outdoor |
| Prize Money: | $899,500 |
| Location: | Charleston, SC, United States |
| Venue: | Family Circle Tennis Center |
| Champs: | Belinda Bencic |
| Champd: | Andreja Klepač /  Magda Linette |
| Before Name: | MUSC Health Women's Open |
The 2022 Charleston Open (branded as the 2022 Credit One Charleston Open for sponsorship reasons) was a women's professional tennis tournament played on outdoor clay courts at the Family Circle Tennis Center on Daniel Island in Charleston, South Carolina. It was the 50th edition of the tournament on the WTA Tour and was classified as a WTA 500 tournament on the 2022 WTA Tour. It was the only event of the clay court season played on green clay.[1]
See main article: 2022 Credit One Charleston Open – Singles.
Ons Jabeur, 6–1, 5–7, 6–4See main article: 2022 Credit One Charleston Open – Doubles.
Magda Linette def. 
Lucie Hradecká / 
Sania Mirza, 6–2, 4–6, [10–7]| Event | W | F | SF | QF | Round of 16 | Round of 32 | Round of 64 | width=85 | Q | width=85 | Q2 | width=85 | Q1 |
| Women's singles | 470 | 305 | 185 | 100 | 55 | 30 | 1 | 25 | 13 | 1 | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Women's doubles | 1 |
| width=130 bgcolor=dfe2e9 | Event | width=80 bgcolor=lime | W | width=85 bgcolor=thistle | F | width=85 bgcolor=ffff00 | SF | width=85 bgcolor=ffebcd | QF | width=85 bgcolor=afeeee | Round of 16 | width=85 bgcolor=afeeee | Round of 32 | width=85 bgcolor=afeeee | Round of 64 | width=85 | Q2 | width=85 | Q1 |
| style=background:#ededed | Women's singles | $158,800 | $98,190 | $49,600 | $19,400 | $9,900 | $5,420 | $3,980 | $2,400 | $1,230 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| style=background:#ededed | Women's doubles | $42,650 | $25,900 | $14,720 | $7,650 | $4,600 |
The following players received wildcards into the main draw:
The following player received entry using a protected ranking into the main draw:
The following players received entry from the qualifying draw:
Robin Anderson Sophie Chang Francesca Di Lorenzo
Ulrikke Eikeri
Nadiia Kichenok Allie Kiick
Gabriela Lee Sachia VickeryThe following players received entry as lucky losers:
Danielle Collins → replaced by Alycia Parks Simona Halep → replaced by Anastasia Gasanova CoCo Vandeweghe Ann Li → replaced by Katarina Zavatska Tereza Martincová → replaced by 
Wang Xiyu
Garbiñe Muguruza → replaced by Claire Liu Hailey Baptiste Nuria Párrizas Díaz → replaced by Wang Xinyu Yuan Yue
Mayar Sherif → replaced by 
Mariam Bolkvadze Elina Svitolina → replaced by Magdalena Fręch Iga Świątek → replaced by 
Heather Watson Madison Brengle (left knee injury) Petra Kvitová (left thigh injury)| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| United States | Caroline Dolehide | China | Zhang Shuai | 32 | 1 | |
| United States | Desirae Krawczyk | Demi Schuurs | 37 | 2 | ||
| Alexa Guarachi | United States | Jessica Pegula | 53 | 4 | ||
| Andreja Klepač | Poland | Magda Linette | 58 | 4 |
The following pair received a wildcard into the doubles main draw:
Lyudmyla Kichenok / Jeļena Ostapenko → replaced by Lyudmyla Kichenok / 
Anastasia Rodionova Magda Linette Nicole Melichar-Martinez → replaced by 
Anna Danilina / Aliaksandra Sasnovich Magda Linette / Bernarda Pera → replaced by 
Tereza Mihalíková / Květa Peschke
Canada
France