The 2022 Copa do Brasil second round was the second round of the 2022 Copa do Brasil football competition. It was played from 8 to 23 March 2022.[1] A total of 40 teams competed in the second round to decide 20 places in the third round of the 2022 Copa do Brasil.[2]
In the second round, each tie was played on a single-legged basis. If the score was level, the match would go straight to the penalty shoot-out to determine the winners.[2] Host teams were settled in the first-round draw.[3]
All times are Brasília time, BRT (UTC−3)|}