| Date: | January 31 – February 6 |
| Edition: | 4th |
| Surface: | Hard (indoor) |
| Location: | Cleveland, Ohio, United States |
| Champs: | Dominic Stricker |
| Champd: |  William Blumberg / Max Schnur |
The 2022 Cleveland Open was a professional tennis tournament played on indoor hard courts. It was the fourth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Cleveland, Ohio, United States between January 31 and February 6, 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Tennys Sandgren | 94 | 1 | ||
 Italy | Andreas Seppi | 101 | 2 | |
 Japan | Yoshihito Nishioka | 119 | 3 | |
 United Kingdom | Liam Broady | 128 | 4 | |
 Austria | Jurij Rodionov | 137 | 5 | |
| Ernesto Escobedo | 141 | 6 | ||
 Ecuador | Emilio Gómez | 153 | 7 | |
| Jack Sock | 157 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
See main article: 2022 Cleveland Open – Singles.
Yoshihito Nishioka 7–5, 6–1.See main article: 2022 Cleveland Open – Doubles.
William Blumberg / Max Schnur def. Robert Galloway / Jackson Withrow 6–3, 7–6(7–4).
