| Date: | 29 August – 4 September |
| Edition: | 16th |
| Surface: | Clay |
| Location: | Como, Italy |
| Champs: | Cedrik-Marcel Stebe |
| Champd: |  Alexander Erler / Lucas Miedler |
The 2022 Città di Como Challenger was a professional tennis tournament played on clay courts. It was the sixteenth edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Como, Italy between 29 August and 4 September 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Italy | Marco Cecchinato | 141 | 1 | |
| Italy | Giulio Zeppieri | 146 | 2 | |
| Italy | Francesco Passaro | 148 | 3 | |
 Serbia | Nikola Milojević | 181 | 4 | |
| Italy | Matteo Arnaldi | 188 | 5 | |
| Italy | Riccardo Bonadio | 189 | 6 | |
| Italy | Stefano Travaglia | 190 | 7 | |
| Italy | Andrea Arnaboldi | 197 | 8 |
The following players received wildcards into the singles main draw:
The following player received entry into the singles main draw as a special exempt:
The following players received entry into the singles main draw as alternates:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2022 Città di Como Challenger – Singles.
Francesco Passaro 7–6(7–2), 6–4.See main article: 2022 Città di Como Challenger – Doubles.
Alexander Erler / Lucas Miedler def. 
Dustin Brown / Julian Lenz 6–1, 7–6(7–3).
