| Champ: |  Nick Kyrgios |
| Runner: |  Yoshihito Nishioka |
| Score: | 6–4, 6–3 |
| Draw: | 48 (6 / 4) |
| Seeds: | 16 |
| Before Name: | Citi Open – Singles |
| After Name: | Mubadala Citi DC Open – Men's singles |
| Main Name: | Washington Open (tennis) Washington Open |
See main article: article and 2022 Citi Open.
Nick Kyrgios defeated Yoshihito Nishioka in the final, 6–4, 6–3 to win the men's singles tennis title at the 2022 Washington Open. It was his second Washington title, following 2019. Kyrgios saved five match points en route to the title, in the quarterfinals against Frances Tiafoe. He also did not drop serve during the tournament.
Jannik Sinner was the reigning champion,[1] but did not compete.
All seeds received a bye into the second round.