See main article: 2022 Chile Open.
Simone Bolelli and Máximo González were the defending champions[1] but Bolelli chose not to participate. González was scheduled to partner Nicolás Jarry, but Jarry withdrew with a right elbow injury before their first round match.
Rafael Matos and Felipe Meligeni Alves won the title, defeating André Göransson and Nathaniel Lammons in the final, 7–6(10–8), 7–6(7–3).