The 2022 Chile Open (also known as the Chile Dove Men+Care Open for sponsorship reasons) was a men's tennis tournament played on outdoor clay courts. It was the 24th edition of the Chile Open, and part of the ATP 250 of the 2022 ATP Tour. It took place in Santiago, Chile from 21 through 27 February 2022.
See main article: 2022 Chile Open – Singles.
Pedro Martínez def. 
Sebastián Báez, 4–6, 6–4, 6–4See main article: 2022 Chile Open – Doubles.
Rafael Matos / Felipe Meligeni Alves def. 
André Göransson / 
Nathaniel Lammons, 7–6(10–8), 7–6(7–3).| Event | W | F | SF | QF | Round of 16 | Round of 32 | width=85 | Q | width=85 | Q2 | width=85 | Q1 |
| Singles | 250 | 150 | 90 | 45 | 20 | 0 | 12 | 6 | 0 | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Doubles | 0 |
| Event | W | F | SF | QF | Round of 16 | Round of 32 | width=85 | Q2 | width=85 | Q1 |
| Singles | $51,045 | $35,735 | $23,660 | $15,780 | $10,210 | $5,570 | $2,785 | $1,390 | ||
| Doubles* | $18,100 | $13,000 | $8,340 | $5,570 | $3,250 |
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Cristian Garín | 19 | 1 | ||
| Spain | Albert Ramos Viñolas | 33 | 2 | |
| Argentina | Federico Delbonis | 37 | 3 | |
| Spain | Pedro Martínez | 62 | 4 | |
| Argentina | Federico Coria | 63 | 5 | |
 Serbia | Miomir Kecmanović | 70 | 6 | |
| Argentina | Sebastián Báez | 72 | 7 | |
| Argentina | Facundo Bagnis | 77 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry using a protected ranking into the singles main draw:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
Roberto Carballés Baena → replaced by Nicolás Kicker 
Casper Ruud → replaced by Bernabé Zapata Miralles
Dominic Thiem → replaced by 
Daniel Elahi Galán| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Brazil | Rafael Matos | Brazil | Felipe Meligeni Alves | 143 | 1 | |
| Spain | Pedro Martínez |  Italy | Andrea Vavassori | 145 | 2 | |
| Sweden | André Göransson | United States | Nathaniel Lammons | 157 | 3 | |
| United States | Nicholas Monroe | United States | Jackson Withrow | 188 | 4 |
The following pairs received wildcards into the doubles main draw:
The following pairs received entry as alternates:
Sergio Galdós / Juan Pablo Varillas Fernando Romboli
Zdeněk Kolář / Nikola Milojević Roberto Carballés Baena / Federico Coria → replaced by Sergio Galdos / Juan Pablo Varillas Marco Cecchinato / Carlos Taberner → replaced by Zdeněk Kolář / Nikola Milojević Marcelo Demoliner / 
Luis David Martínez → replaced by Miomir Kecmanović / Luis David Martínez Máximo González / Nicolás Jarry → replaced by Yannick Hanfmann / Fernando Romboli