| Club: | Charlotte Independence |
| Season: | 2022 |
| League: | USL League One |
| Chrtitle: | Owner |
| Chairman: | Queen City Soccer Club, LLC |
| Mgrtitle: | Head coach |
| Manager: | Mike Jeffries |
| Stadium: | American Legion Memorial Stadium |
| Cup1: | USL1 Playoffs |
| Cup1 Result: | TBD |
| Cup2: | U.S. Open Cup |
| Cup2 Result: | TBD |
| Highest Attendance: | 3,702 (5/15 vs. TUC) |
| Lowest Attendance: | 1,511 (7/29 vs. CV) |
| Average Attendance: | |
| Largest Win: | CLT 6–2 MAD (6/26) CLT 4–0 CV (7/29) CLT 5–1 NC (10/15) |
| Largest Loss: | CHA 7–1 CLT (6/22) |
| Pattern La1: | _adidascampeon21rb |
| Pattern B1: | _adidascampeon21rb |
| Pattern Ra1: | _adidascampeon21rb |
| Shorts1: | 0000FF |
| Socks1: | 0000FF |
| Pattern La2: | _adidascondivo21lgw |
| Pattern B2: | _adidascondivo21lgw |
| Pattern Ra2: | _adidascondivo21lgw |
| Shorts2: | D3D3D3 |
| Socks2: | D3D3D3 |
| American: | true |
| Nextseason: | 2023 |
The 2022 Charlotte Independence season was the 7th season of the club's existence. This will be the club's first season in USL League One, a move the club announced in December 2021 after playing in USL Championship since 2019.[1] It will be the club's first season in the third division of the American soccer pyramid since 2016. The club are coming off of a season that saw them finish 4th in the eastern conference, and advance to the conference semifinals
See main article: 2022 USL League One season.
See main article: 2022 U.S. Open Cup.