| Year: | 2022 |
| Team: | Charleston Southern Buccaneers |
| Sport: | football |
| Conference: | Big South Conference |
| Short Conf: | Big South |
| Record: | 2–8 |
| Conf Record: | 2–3 |
| Head Coach: | Autry Denson |
| Hc Year: | 4th |
| Off Coach: | Klay Koester |
| Oc Year: | 3rd |
| Def Coach: | Zane Vance |
| Dc Year: | 6th |
| Stadium: | Buccaneer Field |
The 2022 Charleston Southern Buccaneers football team represented Charleston Southern University as a member of the Big South Conference during the 2022 NCAA Division I FCS football season. Led by Autry Denson in his fourth and final season as head coach, the Buccaneers compiled an overall record of 2–8 with a mark of 2–3 in conference play, placing in a three-way tie for third in the Big South. Charleston Southern played home games at Buccaneer Field in Charleston, South Carolina.
See also: 2022 Western Carolina Catamounts football team.
See also: 2022 NC State Wolfpack football team.
See also: 2022 Eastern Kentucky Colonels football team.
See also: 2022 Furman Paladins football team.
See also: 2022 Campbell Fighting Camels football team.
See also: 2022 Bryant Bulldogs football team.
See also: 2022 Gardner–Webb Runnin' Bulldogs football team.
See also: 2022 Kennesaw State Owls football team.
See also: 2022 Robert Morris Colonials football team.