| Date: | 14 November – 20 November |
| Edition: | 26th |
| Surface: | Hard (Indoor) |
| Location: | Champaign, Illinois, United States |
| Champs: |  Ben Shelton |
| Champd: | Robert Galloway /  Hans Hach Verdugo |
| Before Name: | JSM Challenger of Champaign–Urbana |
The 2022 Champaign–Urbana Challenger was a professional tennis tournament played on hard courts. It was the 26th edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Champaign, Illinois, United States between November 14 and November 20, 2022.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| United States | Denis Kudla | 104 | 1 | |
| United States | Steve Johnson | 108 | 2 | |
| United States | Christopher Eubanks | 120 | 3 | |
| United States | Ben Shelton | 128 | 4 | |
| United States | Stefan Kozlov | 159 | 5 | |
 Australia | Aleksandar Vukic | 165 | 6 | |
| United States | Aleksandar Kovacevic | 177 | 7 | |
 China | Shang Juncheng | 184 | 8 |
The following players received wildcards into the singles main draw:
Mathis Debru Hunter HeckThe following players received entry from the qualifying draw:
Strong Kirchheimer Patrick Kypson
Iñaki Montes de la Torre Alexander Petrov Ethan QuinnThe following player received entry as a lucky loser:
See main article: 2022 Champaign–Urbana Challenger – Singles.
Ben Shelton def. Aleksandar Vukic 0–6, 6–3, 6–2.See main article: 2022 Champaign–Urbana Challenger – Doubles.
Robert Galloway / Hans Hach Verdugo def. Ezekiel Clark / Alfredo Perez 3–6, 6–3, [10–5].